1st International and 10th National Iranian Conference on Bioinformatics

Comparative genomics of prokaryotes

Paper ID : 1052-ICB10

Authors:

shiva zarean *, samin golchin, negin daneshmand

Zist Fanavari Novin biotechnology institute

Abstract:

Comparative genomics methods enable the reconstruction of bacterial regulatory networks using available experimental data [1]. The analyses of type III secretion and SOS response regulatory networks illustrate instances of convergent and divergent evolution of these regulatory systems, showcasing the power of formal ancestral state reconstruction at inferring the evolutionary history of regulatory networks [1].Gene order in prokaryotes is conserved to a much lesser extent than protein sequences.Only several operons, primarily those that code for physically interacting proteins, are conserved in all or most of the bacterial and archaeal genomes [2]. Multiple genome alignments are a resource for studies on operon rearrangement and disruption, which is central to our understanding of the evolution of prokaryotic genomes.
The coverage of the archaeal genomes was only slightly lower than that of bacterial genomes. The majority of the conserved gene strings are known operons, with the ribosomal super operon being the top scoring string in most genome comparisons [2]. Subsequent comparisons of the sequenced bacterial and archaeal genomes have shown that even most of the operons are extensively rearranged during evolution. Only a few operons, typically coding for physically interacting proteins, are conserved in all or most of the genomes.In this research We were interested in systematically and quantitatively exploring the conservation of gene order among the 25 currently available complete bacterial and archaeal genomes and its dependence on the evolutionary distance between these genomes, and in assessing the potential of such comparisons for identification of previously undetected operons and prediction of gene functions

Keywords:

Comparative genomics, Prokaryotes, Ribosome, Operon, Bacterial genomes

Status : Paper Accepted (Poster Presentation)