1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
The Role of CD81 Gene in the Expression of Tumor-Suppressive miR-let-7 in HCV-Infected Patients with Hepatocellular Carcinoma
Paper ID : 1080-ICB10
Authors:
Niloofar Rahimzadeh, golnaz shirazi, Pegah Javid, Mansoureh Azadeh *
Zist Fanavari Novin biotechnology institute
Abstract:
Hepatocellular carcinoma is the most frequent type of cancer in the world, and it is intimately associated to advanced liver disease [1]. Given the importance of hepatocellular carcinoma, there is a growing interest in studying CD81 function in hepatocytes [2]. Several members of tetraspanin superfamily have been described as managing different virus infectious phases at different stages, including viral entry, viral replication, virion exit, and infectivity which is associated with immunodeficiency disease, including hepatitis C (HCV) which is a serious human pathogen with a high chronicity rate [3,4]. Chronic hepatitis C (CHC) is a virus that causes hepatocellular cancer (HCC) in people [4]. The family of miR-let-7, a kind of short non-coding RNA that regulates the expression of certain genes, contains 12 members of miRNAs [5]. Some of them have demonstrated dysregulation results in the less differentiated cellular phase and development of cell-based disorders like cancer [6]. In this study, the roles of CD81 gene and miR-let-7 were discussed in promotion of hepatocellular carcinoma in HCV-infected patients to validate the related prior reports. The function of CD81 gene was investigated through GeneCards and KEGG databases. MiRWalk and miRBase databases showed the involved members of miR-let-7 family in HCC and related to CD81 gene. According to the bioinformatics analysis, CD81 plays a role in HCV infection, which may lead to the development of HCC by interaction with miR-let-7 downregulation. It is concluded that considering level of miR-let-7 expression may suppress cell line proliferation in HCC. Overall, it seems reasonable to assume that CD81 is associated with HCV and HCC.
Keywords:
HCC; HCV; CHC; miRNA; Bioinformatics
Status : Paper Accepted (Poster Presentation)