1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
the relation between aging process and contributor factors
Paper ID : 1083-ICB10
Authors:
shahab atefi *1, Armin Sharifi2, mehran radak1
1علوم پزشکی کرمانشاه
2دانشکده علوم پزشکی کرمانشاه
Abstract:
Abstract:
No one dares to deny the importance of aging in the different systems that balance our body and mind
arterial system pressure affect the elasticity and the ability in a aged elderly people due to missing multi factors.
In our study, we use Meta annalistic vision to fond essential differentially transcription factor in aging process of cardiac mesenchymal stromal cells.
Methods: We used the GSE129656 dataset that information is available free for all in the NCBI database. The data set was analyzed through using a lima package embedded in the GEO2R NCBI instrument to determine significant differentially expressed genes (DEGs) with a P-value of less than 0.05 in old cardiac mesenchymal stromal cells (cMSCs) cells against young cMSCs. Next, select genes that have a 0.6 change in log2 Fold. After that, we estimate the transcription factors for the various genes expressed on the Enricher site with ChEA2016. Finally, we used Cytoscape 3.4.0 and Gephi 0.9.2 software to construct and analyze a network of differentially expressed transcription factors (DE-TF).
Results: The results showed that there is a transcription factors with different expression (DE-TF) In senescent cells. In addition, the DE-TF is JARID2 which regulation of this was less.
Conclusion: this essay suggests that JARID2 has vital function in aging process of cardiac mesenchymal stromal cells.
Keywords:
#aging process#JARID2#cardiac mesenchymal stromal cells.
Status : Paper Accepted (Poster Presentation)