1st International and 10th National Iranian Conference on Bioinformatics

Investigation of SDCCAG8 gene in COLON ADENOCARCINOMA and the possibility of rs769698229 in hsa-mir-450b-5p

Paper ID : 1092-ICB10

Authors:

ALIASGHAR AKBARINIA *

Naghshejahan

Abstract:

Introduction
Colon cancer is a type of cancer that starts in the colon or rectum.The large intestine forms the organs of the lower gastrointestinal tract.There is more than one type of colon cancer.There are cells in different parts of the gastrointestinal tract that can lead to colon cancer.The most common type of colon cancer starts with adenocarcinoma.Adenocarcinomas form inside the cells that make up the lining of the large intestine or rectum.Cancer may be caused by genetic mutations that can be inherited or acquired.These mutations are not a guarantee of colon cancer, but they do increase the risk.(1)The SDCCAG8 gene encodes a centrosome-related protein.This protein may be involved in the organization of the centrosome during the interphase phase,and mitotic mutations in this gene are associated with renal retinal ciliopathy(2).

Materials and methods
At the NCBI site, the SDCCAG8 gene (involved in interphase and mitosis) was selected(2).At the GEPIA2 site,the expression of this gene was examined,and at the MIRWALK site, the microRNAs that acted on this gene were studied,and at LNCRNASNP2, this microRNA was examined for expression in COLON ADENOCARCINOMA and finally the SNPs affecting this microRNA were examined at the MIRNASNP site.

Discussion
SDCCAG8 gene is more expressed in tumor patients.MIRNA (has-mir-450b-5p) that was selected had a score: 0.85 and np:16, which has a great effect on the SDCCAG8 gene.This MIRNA had an expression of 7.18 in COLON ADENOCARCINOMA.And many SNPs affect this MIRNA(3).

Conclusion
SNPs are high-density natural sequence variations in genomes and are considered as a major genetic source of phenotypic variation within a species and are considered important genetic markers(4).
Based on previous research,it is predicted that SNP rs769698229 will be created between a gene or MIRNA and cause a functional disorder.(3)

Keywords:

Colon, cancer, lnc , snp, gene

Status : Paper Accepted (Poster Presentation)