1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
ApInAPDB: A database of apoptosis-inducing anticancer peptides
Paper ID : 1116-ICB10
Authors:
Naser Faraji1, Alireza Doustmohammadi2, Seyed Shahriar Arab *2, Norelle L Daly3, Ahmad Yari Khosroushahi1
1Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland 4870, Australia
Abstract:
ApInAPDB (http://bioinf.modares.ac.ir/software/ApInAPDB) is manually-collected database of 775 apoptosis-inducing anticancer peptides accumulated from published research articles and databases like DRAMP. ApInAPDB include 748 linear and 27 cyclic peptides having L-amino acids, D-amino acids or both of them. The current version of the database provides information related to a peptide including source, N-terminal modification, C-terminal modification, non-natural amino acid presence, binding target, function, IC50 of peptide, cell lines, and finally binding affinity and etc. Additionally, several physicochemical properties such as isoelectric point, net charge at pH 7, hydrophobicity and GRAVY among others and also 1559 descriptors for QSAR modeling are calculated for almost all peptides. Besides, secondary structure is predicted using Chou-Fasman, GOR, Neural Network algorithms and joint of them. Some user-friendly searching tools are designed to facilitate browsing and achieving the desired results including simple research, advanced research and top categories. Overall, ApInAPDB is the first database provides comprehensive and useful information of apoptosis-inducing anticancer peptides which can be helpful for researchers interested in cancer therapy and peptide design.
Keywords:
peptide; database; apoptosis; anticancer
Status : Paper Accepted (Oral Presentation)