1st International and 10th National Iranian Conference on Bioinformatics

Novel Insight into Pancreatic Adenocarcinoma Pathogenesis Using Three-way Interaction Model

Paper ID : 1123-ICB10

Authors:

Nasibeh Khayer *

Skull Base Research Center, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy associated with a poor prognosis [1]. High-throughput disease-related-gene expression data provide valuable information on gene interaction, leading to more profound insight into pathogenesis. The co-expression analysis is a common approach used to investigate gene-gene interaction. However, such an approach is too simplistic for explaining complex molecular interactions. In this study, we applied a three-way interaction model to capture switch genes whose expression levels modulate the dynamic nature of the co-expression gene relationship between two other genes [2,3]. Subsequently, we determine the biological relevancy of statistically significant triplets in the gene regulatory network and biological pathways. Moreover, we validate in silico the outcome of this research in other related and unrelated gene expression datasets. The results of the current study suggest two critical biological processes which might be involved in PDAC triggering, and in addition, six crucial switch genes may pave the way for identifying drug targets.

Keywords:

Pancreatic ductal adenocarcinoma, Three-way Gene Interaction, Gene Set Enrichment Analysis, Therapeutic Targets.

Status : Paper Accepted (Poster Presentation)