1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
Bioinformatics Evaluation of gene and microRNA through HER2-positive breast cancer
Paper ID : 1159-ICB10
Authors:
Fatemeh Jalali, Fatemeh hamidifar, Mansoureh Azadeh *, pegah javid
Zist Fanavari Novin Biotechnology Department, State Technical and vocational Training Organization, Isfahan, Iran
Abstract:
Breast cancer is the most common cancer in women [reference]. Due to the limitations of common cancer diagnostic tests, the introduction of biomarkers with higher specificity for the diagnosis of breast cancer is important [reference]. The aim of this study was to evaluate the bioinformatics of HER2-positive breast cancer and the resistance mechanisms in this disease caused by the mir-8 family expression. The study was done through genomics databases. The NCBI database was used to search for HER family genes in intracellular signaling pathways. Drug targets for HER2 were then assessed using the GeneCards database. Finally, the role of the mir-8 family in the pathogenesis of HER2 was determined using the MirBase database. According to the data obtained from the NCBI database, the HER family including EGFR (HER1/ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and IGF-IR can activate several oncogenic signaling pathways to stimulate growth. According to GeneCards database, HER2 inhibitor drugs such as trastuzumab, pertuzumab, margotosumab or T-DM1 can be used for suppression of cell growth in the treatment of this cancer. These drugs block the Ras and PI3K/mTOR pathway and prevent cell division. Trastuzumab, as a HER2 antagonist, is one of the approved drugs for this cancer [reference]. The miRBase database showed that downregulation of mir141 in cancer cells has led to resistance to the drug. In addition, the miR-200c /141 cluster, both of which belong to the mir-8 family, plays an important role in the epithelial to mesenchymal transition (EMT) process. The expression of these two miRNAs is inversely correlated with HER2-positive breast cancer. Mir141 plays a prominent role as a metastasis suppressor gene [2]. It is concluded that members of the miR-8 family by targeting HER2 involved in the growth and processes involved in breast cancer could possibly be investigated as diagnostic biomarkers in future studies.
Keywords:
Key words: HER family genes; Mir141; miR-200c; suppressive drugs
Status : Paper Accepted (Poster Presentation)