1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
Bioinformatics evolution of an lncRNA signaling pathway and its related function in colorectal cancer
Paper ID : 1165-ICB10
Authors:
Irsa Alborzi, Maryam Modrek, Pegah Javid, Mansoureh Azadeh *
Zist Fanavari Novin Biotechnology Department, State Technical and Vocational Training Organization, Isfahan, Iran
Abstract:
Genetic investigations have discovered long non-coding RNA (lncRNA) genes in the human genome that do not encode proteins [1]. The non-coding genome, mutations, single nucleotide polymorphisms, copy-number variations, and epigenetic modifications enhance the possibility of altering lncRNA expression levels, which can lead to cell cycle dysregulation and possibly cancer [2]. Our aim of this study was to investigate the role an LncRNA in colorectal cancer (CRC). Through this study, the NCBI obtain some information about colorectal cancer. LncRNAsnp2 database helped to find lncRNA associated with CRC. The interactions between LncRNAs and selected LncRNA with other diseases were found from LncRNAdisease2 database. Based on our research, MALAT-1 (ID :NONHSAT022126.2) was the potential lncRNA in CRC. Another lncRNAs such as SCYL1, LTBP3, SSSCA1, FAM89B, KCNK7, MAP3K11 are involved in the process of CRC as well. MALAT-1 plays role in other diseases such as gallbladder cancer, Pancreatic cancer, and hepatocellular carcinoma too. It is inferred that overexpression of MALAT-1 could promote cell proliferation and promote tumor growth and metastasis in CRC [3]. The results reveal that one of the five pieces (6918 nt-8441 nt) at the 3' end of MALAT-1 plays an essential role in biological processes such as cell migration, invasion, and proliferation. The underlying mechanism was associated with SFPQ gene as a tumour suppressor and PTBP2 as a proto-oncogene. MALAT-1 should bind to SFPQ, freeing PTBP2 and growing cell proliferation and migration. It is concluded that lncRNAs manage numerous vital most cancers traits via their interplay with different mobile macromolecules and satisfactory law of lncRNA transcription would possibly offer indicators of malignant transformation. Recent advances in expertise in the molecular mechanics of lncRNAs have given the capacity to functionally annotate cancer-associated transcripts, making those molecules attractive healing goals withinside the combat in opposition to cancer.
Keywords:
Long Non-coding RNA; MALAT-1; Tumorigenesis; Databases
Status : Paper Accepted (Poster Presentation)