1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
An In Silico Approach Towards Identification of Novel Chalcone Derivatives as Potential Monoamine Oxidases Inhibitors
Paper ID : 1263-ICB10
Authors:
Reza Naderi *1, hafezeh - salehabad2, Neda - Adibpour3, Shohreh mohebi3
1Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan
2Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
3Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract:
Parkinson's disease is a chronic and progressive neurological disorder of the central nervous system that affects and disrupts the functioning of the body's motor system. In Parkinson's disease, Abnormal mitochondrial expression of the enzyme monoamine oxidases B (MAOB) causes the oxidation of compounds such as dopamine, serotonin, norepinephrine, 2-phenylethylamine, etc (1). Oxidation of these compounds leads to the production of reactive oxygen species, which by products ultimately lead to neurotoxic effects such as disruption of neurotransmitters (2). Chalcones are unsaturated carbonyl α and β compounds that exhibit a variety of biological effects. Recent studies show that chalcone derivatives also have good inhibitory effects on the MAOB enzyme (3).Today, various bioinformatics techniques are used in the manufacture and design of medicine to save time and money. Due to the need to develop inhibitory compounds that can selectively and reversibly have an inhibitory effect on the MAOB enzyme, in this study, we decided to design new chalcone derivatives and study molecular docking and how they interact with the active site of the enzyme.
Keywords:
Monoamine Oxidases B (MAOB), Molecular Docking, Chalcone Derivatives, Inhibitor
Status : Paper Accepted (Poster Presentation)