1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
Cross talk between cancer immunity cycle and EMT; new light for study cancer progression
Paper ID : 1307-ICB10
Authors:
امیرعلی حریری1, حمید میرمحمدصادقی1, مینا میریان *2
1بیوتکنولوژی دارویی،دانشکده داروسازی، علوم پزشکی اصفهان، اصفهان، ایران
2بیوتکنولوژی داروییریال دانشکده داروسازی، علوم پزشکی اصفهان، اصفهان، ایران
Abstract:
the immune system becomes involved in a complex set of interactions with different tumor cells. Several sequential actions must be initiated and allowed to proceed and repeatedly expand for an anticancer immune response to lead to the efficient destruction of cancer cells. These processes are known as the cancer Immunity cycle[1]. On the other hand, epithelial to mesenchymal transmission (EMT) is another significant process involved in the development and invasion of cancer[2]. Several similar pathways that regulate EMT are involved in tumor-immune interactions, but little is known about the mechanisms and consequences of interference between these regulatory processes. We performed comprehensive multi-omics analyses to determine the interference between EMT and cancer immunity cycle and their clinical relevance in breast cancer. We obtained relevant multi-omics data containing expression profiles, RNA sequencing data, and clinical data from 1119 breast cancer patients (BRCA, n = 1119) from The Cancer Genome Atlas (TCGA; tcga-data.nci.nih.gov/tcga). The EMT score of cancer cells was measured using the EMT signature, which compares the expression of epithelial marker genes and mesenchymal marker genes. We used two online servers (immune land escape[3] and TIP [4]) for the immune system status and merged these data. Our study demonstrated the existence of complex and dynamic interaction between the cancer immunity cycle and EMT and their effect on cancer prognosis and treatment. Our study highlights the potential for EMT-immune interference as a model for explaining the underlying molecular mechanisms of cancer progression and guiding more effective and generalized cancer.
Keywords:
Epithelial to mesenchymal transmission, Cancer immunity cycle, Omics
Status : Paper Accepted (Poster Presentation)