1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
Evaluation of BRCA1 transcription in Glioblastoma Disease through Bioinformatics analysis
Paper ID : 1412-ICB10
Authors:
Sarah Soltani Tehrani *1, melika golshayan1, منصوره آزاده2, پگاه جاوید3
1Zist Fanavari Novin biotechnology institute
2CEO,zist fanavari novin biotechnology institue
3zist fanavari novin biotechnology institue
Abstract:
Glioblastoma (GBM) is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte [1]. Glioblastomas are often very aggressive and grow into surrounding brain tissue [2] In most cases, the exact underlying cause is unknown. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy, and/or chemotherapy [3]. Therefore, this study aimed to identify the genetic biomarkers for GBM with the concentration on the expression of BRCA1. This study is a theoretical type of bioinformatics, by referring to related databases including GEPIA2, genecards, mirwalk, mirdsnp, mirnasnp. Probably, the overexpression of BRCA1, has-miR-143 and has-miR-504 have an effective role in case of tumor survival. Increaseing the expression of BRCA1 increases the risk of tumorigenesis and metastasis while decreasing its expression reduces the number of cells involved in glioblastoma. It can possibly be used as a diagnostic confirmatory marker and predictor of cancer progression by increasing metastasis, reducing intercellular adhesion, and inhibiting cell death.
Keywords:
GBM; miRNA; Biomaekers
Status : Paper Accepted (Poster Presentation)