1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
Protein Structure Preidction of Glutamate receptor 3
Paper ID : 1419-ICB10
Authors:
Fatemeh Rahimi *1, سید مجتبی قوامی2
1rozitarahimi1374@gmail.com
2گروه باغبانی، دانشکده کشاورزی، دانشگاه ایلام، ایلام، ایران
Abstract:
Metabotropic Glutamate receptor 3 (mGlu3) is a Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. This receptor is a type of Multi-pass membrane protein [1]. mGlu3 is one of the therapeutic targets due to its genetic association with psychiatric disorders [2]. It seems that the use of protein structure modeling and prediction methods on Glutamate receptor 3 protein with the aim of developing more effective and efficient agonists for the treatment, can have a significant effect on promoting Drug Discovery studies. For this purpose, the structure of the protein predicted by I-TASSER, Robetta and SWISS-MODEL server. The best model selected and subjected to ProSA and VADAR servers in order to determine the quality of the predicted structure. The Z-score of the model was -9.31 and the percentage of amino acids in most favored regions was 88.161. Then the protein structure was placed into a membrane model by CHARM-GUI server. Overally the predicted model could be an ideal structure for further studies such as docking. In this regard the result of molecular docking studies using the predicted model as receptor and L-glutamate as ligand shows that the best binding pose has -3.58 kCal/mol.
Keywords:
I-TASSER; SWISS-MODEL; Structure Prediction; CHARM-GUI; Modeling
Status : Paper Accepted (Poster Presentation)