1st International and 10th National Iranian Conference on Bioinformatics
Home Accepted Papers
Evaluation overexpression of miR-451a in decreased CERK gene expression in breast cancer using bioinformatics analysis
Paper ID : 1426-ICB10
Authors:
Nada Hamed Abadh *
دانشگاه تربیت مدرس
Abstract:
MicroRNAs (miRNAs) are one of the essential components of gene regulatory networks today. MiRNAs can down-regulate gene expression by inhibiting translation or stimulating mRNA degradation. In some cases, they can also up-regulate the target gene. MiRNAs participate in regulating biological processes and thereby have the promising potential to act as valuable diagnostic biomarkers and even therapeutic molecules in various diseases.
Bioinformatics analysis is a pivotal initial step of microRNA research, starting from searching, targeting, interaction. In our study, we used bioinformatic analysis data to find out (1) the expression of miR-451a (2), the expression of miR-451a in breast cancer compared to other miRNAs (3), miR-451a target prediction (4), Interaction between miR-451a and cerk (5) the link between miR-451a and breast cancer. Finally, bioinformatics is continuing the development of new tools in the future and in the world, so it is more helpful for cancerous diseases and attractive in molecular therapy.
Keywords:
breast cancer, MicroRNAs, miR-451a, cerk
Status : Paper Accepted (Poster Presentation)