1st International and 10th National Iranian Conference on Bioinformatics

Associated Gene Expression Profiles in Pathogenesis of Lung Adenocarcinoma

Paper ID : 1458-ICB10

Authors:

Sajad Jandaghian *

Kashan University

Abstract:

Lung cancer is the leading cause of cancer-related deaths in men and the second-leading cause in women worldwide and its occurrence and mortality are heavily influenced by cigarette smoking patterns. Based on histopathology assessment lung cancer can be divided into two general subtypes, non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) between which the former is the more common type. Lung adenocarcinoma (LAUD) is the most common among the three histological forms of NSCLC. It is speculated that subclasses of cancer may be related to different cells of origin and their related microenvironments NSCLS can be defined as an invasive and complex disease because it cannot be assessed by a single genetic alteration or a particular biological pathway.

Lung cancer is the leading cause of cancer-related deaths in men and the second-leading cause in women worldwide and its occurrence and mortality are heavily influenced by cigarette smoking patterns. Based on histopathology assessment lung cancer can be divided into two general subtypes, non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) between which the former is the more common type. Lung adenocarcinoma (LAUD) is the most common among the three histological forms of NSCLC. It is speculated that subclasses of cancer may be related to different cells of origin and their related microenvironments NSCLS can be defined as an invasive and complex disease because it cannot be assessed by a single genetic alteration or a particular biological pathway. This study was conducted through analysis of microarray data acquired from the GEO database. The analysis was conducted in an R language environment. The DEGs (Differentially Expressed Gene) related to LAUD cases were identified and gene profiles related to these set of DEGs was subsequently obtained.

Keywords:

Lung cancer, LAUD, Microarray, DEG, Gene profile

Status : Paper Accepted (Poster Presentation)